What characterizes the abnormalities in Sickle Cell Disease?

Prepare for the Rutgers Dynamics of Healthcare Test with flashcards and multiple choice questions. Each question is accompanied by explanations. Get ready to ace your exam!

The hallmark of Sickle Cell Disease is the presence of abnormal-shaped erythrocytes, or red blood cells. In this condition, the red blood cells become rigid and form a characteristic sickle or crescent shape due to a mutation in the hemoglobin gene. This altered shape impacts the red blood cells' ability to flow smoothly through blood vessels and leads to various complications, including vaso-occlusive crises, where blood flow is obstructed in the small vessels, resulting in pain and potential organ damage.

The abnormal shape of the erythrocytes is critical not only because it causes physical blockages but also because it leads to hemolysis (the destruction of red blood cells), chronic anemia, and increased risk for infections due to spleen dysfunction. Overall, the sickle-shaped cells adversely affect the entire circulatory system and contribute significantly to the clinical features of Sickle Cell Disease, making this option the most accurate answer.

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